Advances in genome sequencing and related technology have led to unprecedented pace in identifying genomic and epigenetic changes associated with human health and disease. Nonetheless, validating their biological functions and exploring them as potential drug targets remain time and cost consuming. Exciting advances on genome editing tools using CRISPR system can be employed for this purpose. Here Le will discuss the exciting genome engineering technology that can be deployed as versatile discovery and therapeutics tool for precision medicine. He will highlight how genomics analysis could be integrated to transform our ability to understand and treat complex diseases such as cancer.